Key result
Handgrip exercise-induced FABP4 changes strongly correlate with MSNA changes in healthy subjects.
Why the study?
Elevated adrenergic input contributes to elevated serum FABP4, but the relationship between serum FABP4 and efferent sympathetic nerve activity remains poorly understood.
Does isometric handgrip exercise reveal a relationship between serum FABP4 and muscle sympathetic nerve activity in healthy subjects?
Observational (n=21)
Does isometric handgrip exercise reveal a relationship between serum FABP4 and muscle sympathetic nerve activity in healthy subjects?
Acute increases in sympathetic nerve activity during isometric exercise strongly correlate with increases in serum FABP4, suggesting efferent sympathetic drive may regulate FABP4 levels.
Answers are grounded in this paper and cite their sources.
May link acute sympathetic activation to FABP4 in healthy adults; hypothesis-generating and requires validation before any clinical or mechanistic inference.
Fatty acid binding protein 4 (FABP4) is highly expressed in adipocytes. Lipolysis, caused by an elevated adrenergic input, has been suggested to contribute to elevated serum FABP4 levels in patients with cardiovascular diseases. However, the relationship between the serum FABP4 and efferent sympathetic nerve activity remains poorly understood. Twenty-one healthy subjects (average age, 29.1 years; 15 men) performed an isometric handgrip (HG) exercise at 30% of the maximal voluntary contraction until they were fatigued. The beat-by-beat heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) were recorded. Blood samples were collected at rest and at the time of peak fatigue. The MSNA, HR, and systolic BP were significantly increased by the HG exercise (all, p < 0.05). MSNA was obtained from 14 patients. The change in the FABP4 on HG exercise was significantly correlated with the change in MSNA (bursts/100 heartbeats) (R = 0.808, p < 0.001) but not with changes in other parameters, which might, in part, reflect an association of efferent sympathetic drive with FABP4. Meanwhile, resting FABP4 levels were not associated with any parameters including MSNA, in healthy individuals. Future studies on patients with elevated sympathetic activity are warranted to examine the relationship further.
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Hirai et al. (2024) conducted an observational in Healthy (n=21). Isometric handgrip exercise vs. Rest was evaluated on Correlation between change in FABP4 and change in MSNA (R = 0.808, p=<0.001). Isometric handgrip exercise-induced changes in serum FABP4 were correlated with changes in muscle sympathetic nerve activity in healthy subjects.
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