An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter

Q: What are the key findings of this study?

An admittance technology pulmonary artery catheter accurately measured right ventricular end-diastolic volumes in a swine model, yielding values equal to magnetic resonance imaging and foam casts.

Q: What is the clinical evidence from this study?

Population: Hemodynamic perturbations and acute cardiac injury (n=10). Intervention: Admittance technology (AT) pulmonary artery catheter vs. Magnetic resonance imaging and ex vivo RV foam casts. Primary outcome: Right ventricular end-diastolic volumes (p=NS).

Q: What does this research mean for the field?

An admittance technology pulmonary artery catheter accurately measures instantaneous right ventricular pressure-volume loops and end-diastolic volumes comparable to magnetic resonance imaging and foam casts. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mohammed Aslam; Aleksandra Gruslova; Luis A Diaz Sanmartin; Drew Nolen; James John Elliott; Alexander J. Moody; Joel Michalek; Vivek Jani; Fawaz Alenezi; Clay Heighten; J. W. Valvano; Marc D. Feldman

doi:10.1016/j.jacbts.2025.101326

July 30, 2025JACC Basic to Translational ScienceOpen Access

An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter

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Key result

Admittance technology pulmonary artery catheter measures right ventricular end-diastolic volumes as accurately as MRI.

P NS
n=10

Why the study?

Does an admittance technology pulmonary artery catheter accurately measure right ventricular pressure-volume loops compared to MRI and foam casts in a swine model?

Key Points

To develop and validate an admittance technology pulmonary artery catheter capable of measuring instantaneous right ventricular pressure-volume loops.
Evaluated the catheter in vivo across 10 swine subjected to positive and negative hemodynamic perturbations.
Benchmarked right ventricular volumes against magnetic resonance imaging, ex vivo foam casts, and finite element analysis modeling the electric field.
Finite element analysis confirmed the admittance electric field was strictly confined to right ventricular blood volume.
Right ventricular end-diastolic volumes showed no statistically significant difference compared to magnetic resonance imaging and foam casts (P = NS).
The catheter captured anticipated hemodynamic shifts, detecting significant increases in end-diastolic volume after acute cardiac injury (P < 0.001).

Structured PICO

Does an admittance technology pulmonary artery catheter accurately measure right ventricular pressure-volume loops compared to MRI and foam casts in a swine model?

P

Population

10 swine subjected to positive and negative hemodynamic perturbations to validate an admittance technology pulmonary artery catheter.

I

Intervention

Admittance technology (AT) pulmonary artery catheter

C

Comparator

Magnetic resonance imaging and ex vivo right ventricular foam casts

O

Outcome

Right ventricular end-diastolic volumes and pressure-volume loopssurrogate

Main Result

p-value: p=NS

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Implication

A novel admittance technology pulmonary artery catheter accurately measures instantaneous right ventricular pressure-volume loops in a swine model, matching MRI and foam cast measurements.

Abstract

An admittance technology (AT) pulmonary artery catheter was developed to measure instantaneous right ventricular (RV) pressure-volume loops. Admittance RV volumes were validated in vivo through 10 swine subjected to positive and negative hemodynamic perturbations compared with magnetic resonance imaging and ex vivo RV foam casts. Finite element analysis demonstrated the AT electric field was confined to RV blood volume. RV pressure-volume loops demonstrated anticipated changes in all hemodynamics, and end-diastolic volumes were equal to magnetic resonance imaging and foam casts (P = NS). Increasing RV end-diastolic volumes in response to acute cardiac injury were also measured (P < 0.001). We report validating an AT pulmonary artery catheter in a swine model.

Discussion

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Cite This Study

Aslam et al. (2025) studied Hemodynamic perturbations and acute cardiac injury (n=10). Admittance technology (AT) pulmonary artery catheter vs. Magnetic resonance imaging and ex vivo RV foam casts was evaluated on Right ventricular end-diastolic volumes (p=NS). An admittance technology pulmonary artery catheter accurately measured right ventricular end-diastolic volumes in a swine model, yielding values equal to magnetic resonance imaging and foam casts.

synapsesocial.com/papers/6a0980ed36c3abab5045c98f https://doi.org/10.1016/j.jacbts.2025.101326

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An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter

Key Points

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

An Integrated Pressure-Volume Loop and Pulmonary Artery Catheter

Key Points

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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