Key result
Ventricular-arterial decoupling affects ~25% of day-1 sepsis patients, driven by higher arterial and lower LV elastance.
Why the study?
Ventricular-arterial coupling evaluates afterload and left ventricular systolic function interaction, but the chronological demographics of ventricular-arterial decoupling across the clinical course of sepsis and septic shock required description.
How do ventricular-arterial decoupling and its components (Ea and Ees) change over the clinical course in patients with sepsis and septic shock?
Comparison
Patients with vs without ventricular-arterial decoupling (Ea/Ees >= 1.36)
Design
Single-center prospective observational study
Follow-up
Day 14-28
Authors
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Serial V-A coupling assessment may guide sepsis resuscitation timing; extends single-snapshot data but leaves clinical utility open.
Observational (n=71)
No
How do ventricular-arterial decoupling and its components (Ea and Ees) change over the clinical course in patients with sepsis and septic shock?
Absolute Event Rate: 2.8% vs 1.8%
p-value: p=<0.01
Ventricular-arterial decoupling is common in sepsis and septic shock, driven by dynamic alterations in both arterial elastance and left ventricular end-systolic elastance over the clinical course.
Nasu et al. (2022) conducted an observational in Sepsis and septic shock (n=71). Ventricular-arterial decoupling vs. No ventricular-arterial decoupling was evaluated on Arterial elastance (Ea) on day 1 (p=<0.01). Ventricular-arterial decoupling occurred in 25.4% of sepsis patients on day 1, characterized by significantly higher arterial elastance and lower left ventricular end-systolic elastance.
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