Key result
Arterial stiffness, α-synuclein, and cardiac sympathetic denervation potentially drive Parkinson's baroreflex dysfunction.
Why the study?
Although studies suggest baroreflex dysfunction underlies cardiovascular dysregulation in Parkinson's disease, the existing literature on baroreflex function remains unclear.
Population
Patients with Parkinson's disease and animal models of Parkinson's disease
Design
Review
Authors
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No practice change for Parkinson's cardiovascular care; extends mechanistic hypotheses but leaves open targeted interventions.
Baroreflex dysfunction in Parkinson's disease is driven by a combination of central and peripheral mechanisms, contributing to cardiovascular dysregulation.
Sabino‐Carvalho et al. (2021) conducted a review in Parkinson's disease. Baroreflex dysfunction in Parkinson's disease is potentially driven by central and peripheral mechanisms including arterial stiffness, α-synuclein aggregation, and cardiac sympathetic denervation.
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