What question did this study set out to answer?

This research aims to identify cardiovascular disease risk factors in older adults prior to the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus.

March 1, 1990American Journal of Epidemiology

Cardiovascular Disease Risk Factors Prior to the Diagnosis of Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus in a Community of Older Adults

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Population

1,847 men and women aged 40-79 years who had no known diabetes or fasting hyperglycemia at baseline in…

Design

Cohort

Follow-up

10-15 years (mean, 11.9 years)

Authors

JMJanice B. McPhillipsMemorial Hospital of Rhode Island EBElizabeth Barrett‐ConnorUniversity of North Carolina at Chapel Hill DWDeborah L. WingardGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Supports heightened diabetes surveillance in patients with adverse CV profiles; leaves open whether modification alters incidence in prospective trials.

Key Points

This research aims to identify cardiovascular disease risk factors in older adults prior to the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus.
Analyzed cardiovascular risk factors 10-15 years before diagnosis in 1,847 adults aged 40-79 with no known diabetes at baseline.
Measured follow-up outcomes (1984-1987) including normal glucose tolerance, impaired glucose tolerance, and non-insulin-dependent diabetes mellitus.
Used logistic regression analyses to assess the relationship between risk factors and diabetes diagnosis, independent of age and body mass index.
Among the follow-up group, 27.8% had impaired glucose tolerance and 11.9% had non-insulin-dependent diabetes mellitus.
Increased levels of blood pressure, fasting plasma glucose, and triglycerides were found in those with non-insulin-dependent diabetes mellitus compared to those with normal glucose tolerance.
Odds ratios indicated positive associations between risk factors and the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus, particularly in women.

Structured PICO

Population

1,847 men and women aged 40-79 years who had no known diabetes or fasting hyperglycemia at baseline (1972-1974) in Rancho Bernardo, California.

Outcome

Diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus at follow-up (1984-1987)

An adverse cardiovascular risk factor profile precedes the diagnosis of both non-insulin-dependent diabetes mellitus and impaired glucose tolerance by over a decade.

Cite This Study

McPhillips et al. (1990) studied this question.

synapsesocial.com/papers/6a09dd934db7968590519aed https://doi.org/10.1093/oxfordjournals.aje.a115519

Topics

Women and heart disease

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Implication

Supports heightened diabetes surveillance in patients with adverse CV profiles; leaves open whether modification alters incidence in prospective trials.

Cardiovascular Disease Risk Factors Prior to the Diagnosis of Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus in a Community of Older Adults

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiovascular Disease Risk Factors Prior to the Diagnosis of Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus in a Community of Older Adults

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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