Key result
Both large (aOR 0.65; 95% CI 0.49-0.87) and small arterial elasticity (aOR 0.68; 95% CI 0.56-0.83) were significantly associated with a coronary artery calcium score ≥ 300 (p < 0.001 for both).
Why the study?
Are large and small arterial elasticity indices associated with coronary artery calcium scores in healthy adults?
Cohort (n=6,278)
Are large and small arterial elasticity indices associated with coronary artery calcium scores in healthy adults?
Reduced large and small arterial elasticity are independently associated with higher coronary artery calcium scores, suggesting they are markers of subclinical atherosclerosis.
Supports arterial elasticity as noninvasive marker of high CAC; leaves open prospective validation for risk stratification.
OBJECTIVES: Reduced arterial elasticity is a risk factor for coronary artery disease. Our main objective was to evaluate the association between large arterial elasticity (LAE) and small arterial elasticity (SAE) with subclinical atherosclerosis as reflected by the coronary artery calcium score (CACS). METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) includes a multi-ethnic, population-based cohort (n = 6,814), aged 45-84 years, free from clinical cardiovascular disease. We undertook a post hoc analysis of the NHLBI limited access data set of MESA subjects (n = 6,278) to evaluate the association between LAE and SAE with CACS [divided in to 4 categories: none (reference), 1-99, 100-299, and ≥ 300] using multivariable adjusted logistic regression analysis. RESULTS: After adjustments for age, sex, systolic blood pressure, anti-hypertensive medications use, race, smoking, diabetes, high-density lipoprotein and total cholesterol, and high-sensitivity C-reactive protein, both LAE [adjusted odds ratio (aOR) 0.65; 95% CI 0.49-0.87 for CACS ≥ 300] and SAE (aOR 0.68, 95% CI 0.56-0.83 for CACS ≥ 300) were significantly (p < 0.001 for both) associated with a higher CACS. CONCLUSION: Both LAE and SAE, independent of traditional risk factors and inflammation, are associated with subclinical coronary atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Panaich et al. (2012) conducted a cohort in Subclinical atherosclerosis (n=6,278). Large and small arterial elasticity was evaluated on Coronary artery calcium score (CACS) ≥ 300 (aOR 0.65 (LAE), aOR 0.68 (SAE), 95% CI 0.49-0.87 (LAE), 0.56-0.83 (SAE), p=<0.001). Both large (aOR 0.65; 95% CI 0.49-0.87) and small arterial elasticity (aOR 0.68; 95% CI 0.56-0.83) were significantly associated with a coronary artery calcium score ≥ 300 (p < 0.001 for both).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: