Histopathological analysis demonstrates substantial loss of nucleus basalis neurons in Alzheimer disease, suggesting an anatomical basis for neocortical cholinergic deficits.
The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.
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Whitehouse et al. (1981) studied this question.
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