Key result
Higher mean platelet volume linked to ~274% greater odds of central non-dipping BP in T1D.
Why the study?
Hypertensive non-dippers have higher MPV than dippers, but this relationship had never been investigated among people with type 1 diabetes mellitus.
Cross-Sectional (n=62)
No
In adults with type 1 diabetes without cardiovascular disease, a central non-dipping blood pressure pattern is positively associated with increased mean platelet volume and platelet distribution width, suggesting a potential link to elevated cardiovascular risk.
The non-dipping pattern is nighttime systolic blood pressure (SBP) fall of less than 10%. Several studies showed that the non-dipping pattern, increased mean platelet volume (MPV), and platelet distribution width (PDW) are associated with elevated cardiovascular risk. Hypertensives with the non-dipping pattern have higher MPV than the dippers but this relationship was never investigated among people with type 1 diabetes mellitus (T1DM). This study aimed to investigate the association between the central dipping pattern and platelet morphology in T1DM subjects. We measured the central and brachial blood pressure with a validated non-invasive brachial oscillometric device-Arteriograph 24-during twenty-four-hour analysis in T1DM subjects without diagnosed hypertension. The group was divided based on the central dipping pattern for the dippers and the non-dippers. From a total of 62 subjects (32 males) aged 30.1 (25.7-37) years with T1DM duration 15.0 (9.0-20) years, 36 were non-dippers. The non-dipper group had significantly higher MPV (MPV (10.8 [10.3-11.5] vs 10.4 [10.0-10.7] fl; p = 0.041) and PDW (13.2 [11.7-14.9] vs 12.3 [11.7-12.8] fl; p = 0.029) than dipper group. Multivariable logistic regression revealed that MPV (OR 3.74; 95% CI 1.48-9.45; p = 0.005) and PDW (OR 1.91; 95% CI 1.22-3.00; p = 0.005) were positively associated with central non-dipping pattern adjusting for age, sex, smoking status, daily insulin intake, and height. MPV and PDW are positively associated with the central non-dipping pattern among people with T1DM.
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Kulecki et al. (2021) conducted a cross-sectional in Type 1 diabetes mellitus without cardiovascular disease (n=62). Central non-dipping blood pressure pattern vs. Central dipping blood pressure pattern was evaluated on Association of Mean Platelet Volume (MPV) with central non-dipping pattern (OR 3.74, 95% CI 1.48-9.45, p=0.005). Higher mean platelet volume (OR 3.74) and platelet distribution width (OR 1.91) were significantly associated with a central non-dipping blood pressure pattern in adults with type 1 diabetes.
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