Key result
Mean platelet volume and red cell distribution width were significantly higher in prehypertensive non-smokers with a non-dipper blood pressure pattern compared to those with a dipper pattern.
Why the study?
Absence of nocturnal BP dipping predicts cardiovascular damage and poor outcomes, but its association with MPV and RDW in prehypertensive non-smokers was unclear.
Are mean platelet volume and red cell distribution width associated with non-dipping blood pressure in prehypertensive non-smokers?
Cross-Sectional (n=52)
No
Are mean platelet volume and red cell distribution width associated with non-dipping blood pressure in prehypertensive non-smokers?
p-value: p=0.012 for MPV, 0.001 for RDW
Higher mean platelet volume and red cell distribution width are associated with a non-dipping blood pressure pattern in untreated prehypertensive non-smokers.
May support hematologic screening for non-dipping in prehypertension; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE: Absence of nocturnal blood pressure (BP) dipping is associated with poor health outcomes, including increased mortality. Non-dipper BP seems to be a predictor of cardiovascular damage in hypertensive patients. The aim of this study was to investigate the association of the mean platelet volume (MPV) and red cell distribution width (RDW) with nocturnal dipping/non dipping status in newly diagnosed and untreated prehypertensive non-smokers, using ambulatory BP monitoring. RESULTS: Twenty-eight patients (15 males) in the dipper group and 24 patients (11 males) in the non-dipper group were evaluated in this study. The age of patients was 41.64 ± 15.01 and 37.96 ± 15.08 years in the dipper and non-dipper groups, respectively. The rate of nocturnal systolic BP drop in the dipper and non-dipper groups was 13.79 ± 3.35% (10.20-22.10) and 5.96 ± 2.87% (1.10-9.30) (P < 0.001), respectively. Also, the mean rate of nocturnal diastolic BP drop in the dipper and non-dipper groups was 17.02 ± 5.09% (10.30-26.90) and 6.19 ± 2.75% (1.20-9.70) (P < 0.001), respectively. RDW and MPV were significantly higher in non-dipper patients than dipper patients (P = 0.001 and P = 0.012, respectively). Bivariate analysis revealed that MPV was inversely correlated with the nocturnal systolic BP drop (P = 0.005, r = - 0.385). Furthermore, RDW was inversely correlated with systolic BP drop (P = 0.019, r = - 0.324).
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Sadeghi et al. (2019) conducted a cross-sectional in Prehypertension (n=52). Non-dipper blood pressure pattern vs. Dipper blood pressure pattern was evaluated on Mean platelet volume (MPV) and red cell distribution width (RDW) (p=0.012 for MPV, 0.001 for RDW). Mean platelet volume and red cell distribution width were significantly higher in prehypertensive non-smokers with a non-dipper blood pressure pattern compared to those with a dipper pattern.
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