Key result
Elevated mean platelet volume predicts reverse dipper hypertension with ~0.70 AUC.
Why the study?
Little information has been revealed about the relationship between reverse dipper hypertension and mean platelet volume.
Is reverse dipper hypertension associated with increased mean platelet volume in patients with essential hypertension?
Observational (n=317)
Is reverse dipper hypertension associated with increased mean platelet volume in patients with essential hypertension?
Effect estimate: AUC 0.696 (95% CI 0.627-0.764)
p-value: p=.001
Reverse dipper hypertension is associated with increased mean platelet volume, a potential marker of cardiovascular risk, in patients with essential hypertension.
MPV was associated with reverse dipper hypertension; hypothesis-generating and should not yet change practice.
OBJECTIVE: An association between increased mean platelet volume (MPV) and cardiovascular events is well established. Recent studies suggest that a nondipper blood pressure pattern is closely related to increased MPV. Because little information has been revealed about the relationship between reverse dipper hypertension (RDHT) and MPV, we aimed to investigate this relation. METHODS: A total of 317 patients were retrospectively evaluated by analyzing the records of ambulatory blood pressure monitoring (ABPM). Patients were categorized into three groups according to their ABPM values as RDHT (n = 63), non-dipper hypertension (NDHT) (n = 95), and dipper hypertension (DHT) groups (n = 159). MPV and biochemical analyses were recorded from the hospital database. RESULTS: = .001) were found to be associated with RDHT. ROC curve analysis of MPV for prediction of RDHT showed that at the cutoff value of >9,1 fl with a sensitivity of 60% and specificity of 69%, respectively (AUC = 0.696 ± 0.035, 95% CI: 0.627-0.764). Our data show that the RDHT pattern is associated with increased MPV values in patients with essential hypertension.
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Alpsoy et al. (2021) conducted an observational in Essential hypertension (n=317). Mean platelet volume (MPV) vs. Dipper and non-dipper hypertension patterns was evaluated on Prediction of reverse dipper hypertension (RDHT) (AUC 0.696, 95% CI 0.627-0.764, p=.001). Mean platelet volume >9.1 fl predicted reverse dipper hypertension with 60% sensitivity and 69% specificity (AUC 0.696; 95% CI 0.627-0.764).
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