Key result
The lowest quintiles of ambulatory and home blood pressure in subjects aged ≥50 years were associated with significantly higher cardiovascular and all-cause mortality over 5 years.
Why the study?
Do low blood pressure levels determined by ambulatory and home monitoring increase the risk of cardiovascular and all-cause mortality in adults aged 50 and over?
Population
1,226 subjects aged 50 years and over from Ohasama, Japan
Comparison
Lowest quintile of ambulatory blood pressure… vs Other blood pressure quintiles
Design
Cohort
Follow-up
5 years
Authors
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May warrant caution with low out-of-office BP targets in adults ≥50; leaves open reverse causation versus harm.
Cohort (n=1,226)
No
Do low blood pressure levels determined by ambulatory and home monitoring increase the risk of cardiovascular and all-cause mortality in adults aged 50 and over?
Low blood pressure levels measured by ambulatory and home monitoring are associated with increased cardiovascular and all-cause mortality in older adults, demonstrating a J-shaped relationship.
Imai et al. (1996) conducted a cohort in Cerebrovascular and cardiovascular diseases (n=1,226). Low blood pressure levels (lowest quintile) vs. Higher blood pressure quintiles was evaluated on All-cause and cardiovascular mortality. The lowest quintiles of ambulatory and home blood pressure in subjects aged ≥50 years were associated with significantly higher cardiovascular and all-cause mortality over 5 years.
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