Key result
A to I RNA editing by ADARs diversifies the central nervous system transcriptome by altering receptor and channel properties, and its dysregulation is associated with various neurological diseases.
This review highlights the critical role of A to I RNA editing in diversifying transcripts for CNS receptors and channels, impacting normal brain function and disease development.
Supports expanded research on ADAR editing in CNS disorders; leaves open any clinical therapeutic implications.
RNA editing by adenosine deaminases that act on RNA converts adenosines to inosines in coding and non-coding regions of mRNAs. Inosines are interpreted as guanosines and hence, this type of editing can change codons, alter splice patterns, or influence the fate of an RNA. A to I editing is most abundant in the central nervous system (CNS). Here, targets for this type of nucleotide modification frequently encode receptors and channels. In many cases, the editing-induced amino acid exchanges alter the properties of the receptors and channels. Consistently, changes in editing patterns are frequently found associated with diseases of the CNS. In this review we describe the mechanisms of RNA editing and focus on target mRNAs of editing that are functionally relevant to normal and aberrant CNS activity.
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Tariq et al. (2012) conducted a review in Neurological and psychiatric disorders associated with RNA editing. A to I RNA editing by ADARs was evaluated. A to I RNA editing by ADARs diversifies the central nervous system transcriptome by altering receptor and channel properties, and its dysregulation is associated with various neurological diseases.
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