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June 1, 2000Journal of Hypertension

Role of oxidative stress in cardiovascular diseases

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Key result

Oxidative stress may play a crucial role in cardiac and vascular abnormalities in cardiovascular diseases, and antioxidant therapy may prove beneficial in combating these problems.

Why the study?

Does antioxidant therapy improve outcomes in patients with cardiovascular diseases?

Population

Patients with cardiovascular diseases and experimental models

Design

Review

Authors

NDNaranjan S. DhallaSt. Boniface HospitalRTRana M. TemsahUniversity of OttawaTNThomas NetticadanAgriculture and Agri-Food Canada

Discussion

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Implication

Antioxidant therapy should not yet change CVD practice; leaves open whether targeted oxidative stress reduction improves outcomes.

Structured PICO

Does antioxidant therapy improve outcomes in patients with cardiovascular diseases?

P
Population
Patients with cardiovascular diseases (hypertension, atherosclerosis, ischemic heart disease, cardiomyopathies, congestive heart failure) and experimental models
I
Intervention
Antioxidant therapy
O
Outcome
Cardiac and vascular abnormalities

This review highlights the pathophysiological role of oxidative stress in cardiovascular diseases and suggests potential benefits of antioxidant therapy.

Limitations

  • The cause-effect relationship of oxidative stress with cardiovascular diseases remains to be established.

Cite This Study

Dhalla et al. (2000) conducted a review in Cardiovascular diseases. Antioxidant therapy was evaluated. Oxidative stress may play a crucial role in cardiac and vascular abnormalities in cardiovascular diseases, and antioxidant therapy may prove beneficial in combating these problems.

synapsesocial.com/papers/6a09ebb459b902245b4641bahttps://doi.org/10.1097/00004872-200018060-00002
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