Key result
Single-pill antihypertensive combinations increase adherence and lower cardiovascular risk versus free combinations.
Why the study?
High medical adherence is required to achieve hypertension treatment goals, but the majority of hypertensive patients show low adherence.
Do single-pill combinations of antihypertensive drugs improve adherence and reduce cardiovascular outcomes in hypertensive patients compared to free combinations?
Do single-pill combinations of antihypertensive drugs improve adherence and reduce cardiovascular outcomes in hypertensive patients compared to free combinations?
Single-pill combinations of antihypertensive medications are an effective strategy to improve medication adherence and cardiovascular outcomes in patients with hypertension.
Supports adherence with single-pill antihypertensives; leaves open randomized confirmation of outcome benefits.
High medical adherence is a prerequisite for achieving goals in the treatment of hypertension (HTN). This review describes the factors influencing adherence, ways of its assessment and methods of increasing medical adherence in hypertensive patients. The majority of patients with HTN showed low adherence to treatment, which requires finding ways to solve this problem. A number of studies demonstrated that single-pill combinations of antihypertensive drugs can make a significant contribution to solving such a complex problem as low adherence. The use of single-pill combinations (SPC) of antihypertensive drugs can be considered as one of the main and important tools for increasing adherence to antihypertensive therapy. Recently published data have been demonstrated that the triple SPC of amlodipine/indapamide/perindopril, compared with free combinations of the same components, already after one year of therapy helps to increase adherence to therapy and reduce the risk of cardiovascular outcomes and patient costs
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Космачева et al. (2025) conducted a review in Hypertension. Single-pill combinations (SPC) of antihypertensive drugs vs. Free combinations of the same components was evaluated. Single-pill combinations of antihypertensive drugs, such as amlodipine/indapamide/perindopril, increase adherence and reduce the risk of cardiovascular outcomes compared with free combinations.
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