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In Drosophila, PINK1 is required to recruit Parkin to dysfunctional mitochondria, where they mediate the ubiquitination of the profusion factor Mitofusin (Mfn) to regulate mitochondrial dynamics and promote autophagic degradation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 1, 2010Proceedings of the National Academy of SciencesOpen Access

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

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EZElena ZivianiUniversity of Padua RTRan TaoNanjing University of Information Science and Technology AWAlexander J. WhitworthUniversity of Cambridge

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Ziviani et al. (2010) studied this question.

synapsesocial.com/papers/6a09f9a2b0d552aa8b45fca5 https://doi.org/10.1073/pnas.0913485107

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March 1, 2010Proceedings of the National Academy of SciencesOpen Access

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

View Full Paper

Ask AI

Bookmark

Authors

EZElena ZivianiUniversity of Padua RTRan TaoNanjing University of Information Science and Technology AWAlexander J. WhitworthUniversity of Cambridge

Discussion

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Ziviani et al. (2010) studied this question.

synapsesocial.com/papers/6a09f9a2b0d552aa8b45fca5 https://doi.org/10.1073/pnas.0913485107

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