Digoxin and Risk of Death in Adults With Atrial Fibrillation
Key result
Digoxin use in AF without heart failure is linked to ~71% higher mortality risk.
- HR 1.71
- 95% CI 1.52-1.93
- P<0.001
- n=14,787
Authors
Discussion
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Member takes
Implication
Supports caution with digoxin in AF without HF; observational association leaves open causality and need for RCTs.
Study Design
Type
Cohort (n=14,787)
Multicenter
Yes
PICO
P
Population
Incident atrial fibrillation (n=14,787)
I
Intervention / Comparator
Digoxin vs No digoxin use
O
Primary Outcome
Death — HR 1.71 (1.52-1.93), p=<0.001
Main Result
Effect estimate: HR 1.71 (95% CI 1.52-1.93)
Absolute Event Rate: 8.3% vs 4.9%
p-value: p=<0.001
Cite This Study
Freeman et al. (2014) conducted a cohort in Incident atrial fibrillation (n=14,787). Digoxin vs. No digoxin use was evaluated on Death (HR 1.71, 95% CI 1.52-1.93, p=<0.001). Incident digoxin use in adults with atrial fibrillation and no heart failure was associated with a 71% higher risk of death (HR 1.71; 95% CI 1.52-1.93) and a 63% higher risk of hospitalization.