Key result
Digoxin use in patients with atrial fibrillation was associated with an increased risk of death from any cause (RR 1.29; 95% CI 1.16-1.43), or 19 additional deaths per 1000 person-years.
Why the study?
Does digoxin use increase the risk of death from any cause in patients with atrial fibrillation?
Population
586,594 patients with atrial fibrillation from 22 studies
Comparison
Digoxin use vs No digoxin use
Design
Meta-analysis
Authors
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May warrant caution with digoxin in AF; leaves open causality pending RCTs.
Meta-Analysis (n=586,594)
Does digoxin use increase the risk of death from any cause in patients with atrial fibrillation?
Relative Risk: 1.29 (95% CI 1.16–1.43)
Digoxin use in patients with atrial fibrillation is associated with a significantly increased risk of all-cause mortality, suggesting a need to reconsider its use in this population.
Zeng et al. (2016) conducted a meta-analysis in Atrial Fibrillation (n=586,594). Digoxin vs. No digoxin was evaluated on death from any cause (RR 1.29, 95% CI 1.16-1.43). Digoxin use in patients with atrial fibrillation was associated with an increased risk of death from any cause (RR 1.29; 95% CI 1.16-1.43), or 19 additional deaths per 1000 person-years.
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