Key result
In high-risk patients with complex coronary disease deemed ineligible for surgery, percutaneous coronary intervention resulted in a 30-day mortality of 5.6%, matching the predicted STS surgical risk.
Why the study?
Guidelines rarely address revascularization decision-making for surgically turned-down high-risk cases, who are routinely excluded from trials, leaving the risk-benefit balance and health status outcomes of PCI uncertain.
Does percutaneous coronary intervention (PCI) improve outcomes in high-risk patients with complex coronary disease who are surgically turned down?
Does percutaneous coronary intervention (PCI) improve outcomes in high-risk patients with complex coronary disease who are surgically turned down?
PCI in high-risk patients deemed ineligible for CABG provides acceptable short-term mortality and significant improvements in quality of life and angina frequency.
Answers are grounded in this paper and cite their sources.
May support PCI consideration in high-risk surgical turndowns; leaves open randomized trials for confirmation.
Current guidelines, rarely if at all, address decision-making for revascularization when bypass surgery is not a possibility for high-risk cases. Patients who are surgically turned down are routinely excluded from clinical trials, even though they remain symptomatic. Furthermore, the reasons for surgical ineligibility are often times not captured in standardized risk models. There is no data regarding health status outcomes following PCI procedures in these patients and the ultimate question remains whether the benefits of PCI outweigh its risks in this controversial subpopulation. When CHIP (Complex High risk Indicated Percutaneous coronary interventions) is selected for these very complex individuals, there is no unanimity regarding the goals for interventional revascularization (for instance, the ambition to achieve completeness of revascularization vs. more targeted or selective PCI). The recognition that, worldwide, these patients are becoming increasingly prevalent and increasingly commonplace in the cardiac catheterization labs, along with the momentum for more complex interventional procedures and expanding skillsets, gives us a timely opportunity to better examine the outcomes for these patients and inform clinical decision-making.
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Achim et al. (2022) conducted a review in Coronary artery disease in surgical turndown patients (n=750). Percutaneous coronary intervention (PCI) vs. Predicted STS surgical risk was evaluated on 30-day mortality. In high-risk patients with complex coronary disease deemed ineligible for surgery, percutaneous coronary intervention resulted in a 30-day mortality of 5.6%, matching the predicted STS surgical risk.
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