Answers are grounded in this paper and cite their sources.
Cohort analysis uncovers combined genetic and environmental drivers of DNA methylation variability in cord blood, highlighting complex gene-environment interactions in early life.
Genetic variation and environmental exposures are amongst the main factors associated with inter-individual DNA methylation variability. However, the prevalence and genomic context of individual, additive, and interactive gene-environment effects remains unclear. We present RAMEN, an R package that dissects genome-exposome contributions to microarray Variably Methylated Loci using machine learning and statistical techniques. Analyzing cord blood samples from CHILD and PREDO (overall n = 1662), we identify genetic variants as key contributors to DNA methylation variability, usually in additive and interactive combinations with the environment. We provide a detailed catalogue of cord blood Variably Methylated Loci and the gene-environment contribution to their variability.
No takes yet. Share an insight, caveat, or question.
Navarro‐Delgado et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: