Key result
Among children who developed arthritis after HPV-77-DK 12 rubella vaccination, definite recurrent attacks occurred in 28% at 3 years, with intervals between attacks increasing over time.
Why the study?
What is the long-term course of arthritis following HPV-77-DK 12 rubella vaccination in children?
Cohort (n=39)
What is the long-term course of arthritis following HPV-77-DK 12 rubella vaccination in children?
Arthritis following HPV-77-DK 12 rubella vaccination can be recurrent over a 3-year period, though attacks appear to decrease in frequency over time.
May require extended monitoring for recurrent arthritis after HPV-77-DK12 vaccination; leaves open risks with modern rubella strains.
Thirty-nine of 40 children who developed arthritis following vaccination with HPV-77-DK 12 rubella vaccine were followed up three years after vaccination. Definite recurrent attacks of arthritis occurred in 11 children (28%) and possible recurrences in 7 (18%). The knee was the joint most commonly involved (78%). Duration of each attack was from one to five days with complete clearing between attacks. With time, the intervals between attacks increased and in most children the attacks appear to have stopped.
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George R. Thompson (1973) conducted a cohort in Arthritis following rubella vaccination (n=39). HPV-77-DK 12 rubella vaccine was evaluated on Definite recurrent attacks of arthritis. Among children who developed arthritis after HPV-77-DK 12 rubella vaccination, definite recurrent attacks occurred in 28% at 3 years, with intervals between attacks increasing over time.
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