Key result
Third-trimester pregnancy is linked to a ~36% higher myocardial performance index versus nonpregnant controls.
Why the study?
Pregnancy induces cardiovascular changes, particularly in LV systolic and diastolic function, prompting the evaluation of LV function changes using tissue Doppler imaging in third-trimester pregnant women.
Does third-trimester pregnancy alter left ventricular diastolic function and myocardial performance index compared to nonpregnant women?
Cross-Sectional (n=126)
Does third-trimester pregnancy alter left ventricular diastolic function and myocardial performance index compared to nonpregnant women?
Third-trimester pregnancy is associated with structural and functional cardiac changes, including a significantly increased myocardial performance index reflecting altered global left ventricular function.
Alerts clinicians to MPI shifts on third-trimester echocardiography; leaves open prognostic value and need for longitudinal validation.
BACKGROUND: The pregnancy process is characterized by several changes in the cardiovascular system, especially in left ventricle (LV) systolic and diastolic function. Tissue Doppler imaging (TDI) is a useful tool to evaluate global LV function. This study investigated changes in LV functions using TDI in third-trimester pregnant women. METHODS: A total of 86 consecutive third-trimester healthy pregnant women and 40 age-matched nonpregnant healthy women (control group) were enrolled in this cross-sectional study. LV diameter, standard Doppler and tissue Doppler parameters, and myocardial performance index (MPI) were measured for all patients. RESULTS: There was no significant difference in baseline characteristics between the pregnant and control groups. However, the cardiac chamber diameter was larger, the Am velocity was higher, and the E velocity, Em velocity, and E/A ratio were lower in the pregnant group. In addition, the MPI was significantly higher in the pregnant group compared to the control group (0.57 ± 0.11 vs 0.42 ± 0.02, P < .001). Correlation analysis showed that gestational week was positively correlated with the MPI (r = .407, P = .003). CONCLUSIONS: Detailed assessment of cardiac function is important during pregnancy. We demonstrated that pregnancy was associated with a significantly increased MPI, as well as structural and functional changes.
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Güngören et al. (2019) conducted a cross-sectional in Pregnancy (n=126). Third-trimester pregnancy vs. Nonpregnant healthy women was evaluated on Myocardial performance index (MPI) (p=< .001). Third-trimester pregnancy was associated with a significantly higher myocardial performance index compared to nonpregnant controls (0.57 ± 0.11 vs 0.42 ± 0.02, P < .001).
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