Why the study?
AF is common in the elderly but rare in the young, yet the age-related changes that promote AF remain not fully understood.
Does aging increase vulnerability to atrial fibrillation and susceptibility to action potential alternans in a sheep model?
Population
Conscious young and old sheep and their isolated atrial myocytes
Comparison
Old sheep vs young sheep
Design
Animal experimental study
Authors
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Hypothesis-generating for age-related AF mechanisms in sheep; leaves open human translation.
Does aging increase vulnerability to atrial fibrillation and susceptibility to action potential alternans in a sheep model?
Aging in a sheep model is associated with increased vulnerability to atrial fibrillation and susceptibility to action potential alternans, driven by calcium handling instabilities at low rates and action potential restitution at high rates.
Pearman et al. (2018) studied this question.
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