Key result
In sheep atrial myocytes, ageing increases intracellular Ca buffering, which decreases systolic Ca2+ transient amplitude and decay kinetics, while sarcoplasmic reticulum Ca content increases.
Population
Single atrial myocytes from young and old Welsh Mountain sheep
Comparison
Ageing (old sheep) vs Young sheep
Design
Preclinical
Authors
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Does not inform clinical practice; hypothesis-generating for age-related atrial Ca2+ remodeling mechanisms.
Increased intracellular calcium buffering is a novel mechanism that decreases systolic calcium in aged atria, contributing to our understanding of age-related atrial remodeling.
Clarke et al. (2017) studied Ageing in atrial myocytes. Old age vs. Young age was evaluated on Intracellular Ca2+ homeostasis (free Ca2+ transient amplitude, rate of decay, SR Ca content). In sheep atrial myocytes, ageing increases intracellular Ca buffering, which decreases systolic Ca2+ transient amplitude and decay kinetics, while sarcoplasmic reticulum Ca content increases.
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