February 27, 2014Journal of Cardiovascular Electrophysiology

Oxidation‐ and CaMKII‐Mediated Sarcoplasmic Reticulum Ca2+ Leak Triggers Atrial Fibrillation in Aging

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Population

Aged (24 months, n=30) and young adult (4-5 months, n=34) mice

Comparison

Intraesophageal atrial electrical stimulation… vs Young adult mice; untreated aged atrial myocytes

Design

Preclinical

Authors

XGXiaoxiao GuoCapital University SYSu YuanGeneral Cardiology ZLZhenyu LiuAnhui Medical University

Discussion

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Implication

Hypothesis-generating for CaMKII-targeted AF therapies in aging; leaves open human translation pending further validation.

Structured PICO

Population

Aged (24 months, n=30) and young adult (4-5 months, n=34) mice

Intervention

Intraesophageal atrial electrical stimulation protocol; in vitro treatment of atrial myocytes with selective CaMKII inhibitor (KN-93), antioxidant reagent (DTT), or PKA inhibitor (H-89)

Comparator

Young adult mice (for in vivo AF induction); untreated aged atrial myocytes (for in vitro cellular assays)

Outcome

Susceptibility to atrial fibrillation (AF induction rate), diastolic SR Ca2+ leak, and arrhythmogenic Ca2+ activitiessurrogate

Aging increases RyR2 oxidation and CaMKII-phosphorylation, leading to diastolic SR Ca2+ leak and heightened susceptibility to atrial fibrillation.

Cite This Study

Guo et al. (2014) studied this question.

synapsesocial.com/papers/6a6fbd03f44fa9f079dd37cc https://doi.org/10.1111/jce.12395

Topics

Atrial fibrillation Persistent AF management

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Oxidation‐ and CaMKII‐Mediated Sarcoplasmic Reticulum Ca2+ Leak Triggers Atrial Fibrillation in Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Oxidation‐ and CaMKII‐Mediated Sarcoplasmic Reticulum Ca2+ Leak Triggers Atrial Fibrillation in Aging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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