Key result
Rapid atrial pacing-induced atrial fibrillation and aging significantly increased calpain 1 protein expression and decreased L-type calcium channel a1c subunit expression in canine left atria.
Why the study?
Does aging and rapid atrial pacing-induced AF alter the expression of atrial calpains and cause electrical and structural remodeling in a canine model?
Population
28 mongrel canines, weighing 18-26 kg, without structural heart disease.
Comparison
Persistent atrial fibrillation induced by… vs Sinus rhythm control groups.
Design
Preclinical, Canines from both age groups were randomly divided into 4 groups
Follow-up
Persistent AF for at least 5 days
Authors
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May implicate calpain 1 in age-related AF remodeling; leaves open human therapeutic relevance.
Does aging and rapid atrial pacing-induced AF alter the expression of atrial calpains and cause electrical and structural remodeling in a canine model?
Absolute Event Rate: 0.78% vs 0.47%
p-value: p=<0.05
Age-related alterations in atrial tissues, including accelerated fibrosis and apoptosis, are associated with increased calpain 1 expression, potentially creating a substrate conducive to atrial fibrillation.
Xu et al. (2013) studied Atrial fibrillation and aging (n=28). Rapid atrial pacing-induced atrial fibrillation vs. Sinus rhythm was evaluated on Calpain 1 protein expression (aged AF vs aged SR) (p=<0.05). Rapid atrial pacing-induced atrial fibrillation and aging significantly increased calpain 1 protein expression and decreased L-type calcium channel a1c subunit expression in canine left atria.
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