Key result
Calpain activity was significantly increased in paroxysmal (2-fold, P<0.001) and persistent AF (3-fold, P<0.001) compared to controls, correlating with structural and electrical remodeling.
Population
Right atrial appendages from patients with paroxysmal or persistent lone atrial fibrillation and controls in…
Design
Case-control
Authors
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Calpain may drive AF remodeling; hypothesis-generating for inhibition trials but should not yet change practice.
Observational (n=27)
p-value: p=<0.001
Calpain activity is induced during atrial fibrillation and correlates with structural and electrical remodeling, suggesting it links calcium overload to cellular adaptation.
B Brundel (2002) conducted an observational in Atrial fibrillation (n=27). Atrial fibrillation (paroxysmal or persistent) vs. Sinus rhythm controls undergoing CABG was evaluated on Calpain activity (p=<0.001). Calpain activity was significantly increased in paroxysmal (2-fold, P<0.001) and persistent AF (3-fold, P<0.001) compared to controls, correlating with structural and electrical remodeling.
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