July 1, 2002AJP Heart and Circulatory Physiology
Calpains and cytokines in fibrillating human atria
Population
32 patients undergoing open heart surgery, including 16 with chronic atrial fibrillation (AF)
Design
Case-control
Authors
Discussion
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Member takes
Implication
Calpain I activation associated with permanent AF remodeling; hypothesis-generating for targeted inhibition before clinical consideration.
Structured PICO
P
Population
32 patients undergoing open heart surgery, including 16 with chronic atrial fibrillation (AF)
C
Comparator
16 patients in sinus rhythm (SR) undergoing open heart surgery
O
Outcome
Atrial expression of calpain I and II, calpastatin, troponin T (TnT), troponin C (TnC), cytokines (IL-1 beta, IL-2, IL-6, IL-8, IL-10, TGF-beta 1, TNF-alpha), and total calpain enzymatic activitysurrogate
Atria of patients with permanent AF demonstrate calpain I activation, suggesting a mechanism for structural remodeling and contractile dysfunction, without concurrent tissue cytokine activation.
Cite This Study
Goette et al. (2002) studied this question.