Why the study?
Does verapamil suppress discordant repolarization alternans and prevent initiation of atrial fibrillation in patients without structural heart disease?
Population
19 patients with atrial fibrillation without structural heart disease undergoing electrophysiological studies
Comparison
Verapamil administration during rapid atrial… vs Baseline electrophysiological measurements in…
Design
Cohort
Authors
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Supports mechanistic insight into calcium-channel blockade; hypothesis-generating for atrial fibrillation prevention and requires prospective validation.
Does verapamil suppress discordant repolarization alternans and prevent initiation of atrial fibrillation in patients without structural heart disease?
Verapamil suppresses discordant atrial repolarization alternans, providing a potential mechanism for how calcium-channel blockers prevent the initiation of atrial fibrillation.
Hiromoto et al. (2005) studied this question.
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