Key result
Mild carotid plaques favor anterior and posterior sections, with lateral involvement increasing from CCA to ICA.
Why the study?
The study was designed to evaluate whether the outer wall at the carotid bifurcation is the most common site of atherosclerotic plaque deposition due to low shear stress, and whether common sites differ between early and late stages.
Population
569 patients with <50% stenosis of the common and internal carotid arteries
Comparison
Plaque distribution across anterior, medial, posterior, and lateral cross-sections
Design
Observational study
Authors
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Challenges low-shear lateral plaque hypothesis in mild carotid stenosis; hypothesis-generating for hemodynamic models without practice change.
Observational (n=569)
No
Absolute Event Rate: 22.5% vs 14%
p-value: p=<.001
Atherosclerotic plaques in the carotid artery predominantly occur in the anterior and posterior sections, challenging the hypothesis that they primarily affect the lateral section due to low shear stress.
Yang et al. (2022) conducted an observational in Mild carotid stenosis (n=569). Duplex ultrasound was evaluated on Axial distribution of lateral section plaques (ICA vs CCA) (p=<.001). Atherosclerotic plaques in mild carotid stenosis preferentially developed in the anterior and posterior sections, with lateral section plaque development significantly increasing from the CCA to ICA.
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