Why the study?
Does a high EASIX score predict worse recurrence-free and overall survival in patients with UTUC undergoing radical nephroureterectomy?
Population
Patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU)
Comparison
High endothelial activation and stress index score vs Low EASIX score (≤1.27)
Design
Cohort
Follow-up
5 years
Key result
A high endothelial activation and stress index score was independently associated with worse recurrence-free survival (HR 1.68) and overall survival (HR 1.71) in upper tract urothelial carcinoma.
Authors
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Supports EASIX for UTUC prognostication; hypothesis-generating and requires prospective validation.
Cohort (n=380)
Yes
Does a high EASIX score predict worse recurrence-free and overall survival in patients with UTUC undergoing radical nephroureterectomy?
Effect estimate: HR 1.68 (95% CI 1.22-2.30)
Absolute Event Rate: 13% vs 23.4%
p-value: p=0.001
A high EASIX score is a significant prognostic factor for worse recurrence-free and overall survival in patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy.
Gu et al. (2022) conducted a cohort in Upper tract urothelial carcinoma (n=380). High EASIX score (>1.27) vs. Low EASIX score (≤1.27) was evaluated on Recurrence-free survival (median months) (HR 1.68, 95% CI 1.22-2.30, p=0.001). A high endothelial activation and stress index score was independently associated with worse recurrence-free survival (HR 1.68) and overall survival (HR 1.71) in upper tract urothelial carcinoma.