Key result
Intensive insulin therapy reduced the long-term risk of incident hypertension by 24% (HR 0.76; 95% CI 0.64-0.92) compared to conventional therapy in patients with type 1 diabetes.
Why the study?
Does intensive insulin therapy reduce incident hypertension in patients with Type 1 Diabetes Mellitus?
RCT (n=1,441)
Does intensive insulin therapy reduce incident hypertension in patients with Type 1 Diabetes Mellitus?
Effect estimate: HR 0.76 (95% CI 0.64-0.92)
Intensive insulin therapy and improved glycemic control significantly reduce the long-term risk of developing hypertension in patients with type 1 diabetes.
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Intensive insulin may lower hypertension risk in type 1 diabetes; leaves open causal confirmation from RCTs.
Ian H. de Boer (2008) conducted an RCT in Type 1 Diabetes Mellitus (n=1,441). Intensive insulin therapy vs. Conventional therapy was evaluated on Incident hypertension (2 consecutive study visits with SBP ≥140 mm Hg, DBP ≥90 mm Hg, or use of antihypertensive medications) (HR 0.76, 95% CI 0.64-0.92). Intensive insulin therapy reduced the long-term risk of incident hypertension by 24% (HR 0.76; 95% CI 0.64-0.92) compared to conventional therapy in patients with type 1 diabetes.
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