Key result
BNP levels were significantly higher in early-onset preeclampsia (61.35 pg/mL) compared to late-onset preeclampsia (32.4 pg/mL) and healthy pregnant women (10.05 pg/mL) (p<0.001).
Why the study?
Are B-type natriuretic peptide (BNP) levels elevated in early-onset and late-onset preeclampsia compared to healthy pregnancies?
Observational (n=80)
Are B-type natriuretic peptide (BNP) levels elevated in early-onset and late-onset preeclampsia compared to healthy pregnancies?
Absolute Event Rate: 61.35% vs 32.4%
p-value: p=<0.001
BNP levels are significantly elevated in preeclampsia, particularly in early-onset disease, and a cut-off of <24.5 pg/mL has a high negative predictive value for excluding the condition.
BNP elevation in early-onset preeclampsia supports biomarker exploration; hypothesis-generating and requires prospective validation before any diagnostic use.
BACKGROUND: We compared B-type natriuretic peptide (BNP) levels, clinical and laboratory findings in early-onset preeclampsia (EOP), late-onset preeclampsia (LOP) and healthy pregnant groups. METHODS: We studied 40 healthy pregnant and 40 preeclamptic patients. Preeclamptics were divided in two groups, the EOP group (n=20) and LOP group (n=20), according to gestational age at the onset of disease. The distinction criterion for early- vs. late-onset was set as week 34 of gestation. The concentration of the BNP levels was measured by a sandwich fluorescence immunoassay. For statistical analysis of the clinical and laboratory findings non-parametric methods were applied. RESULTS: BNP levels were higher in EOP [61.35 (36.95-93.25) pg/mL] and LOP patients [32.4 (19.15-39.2) pg/mL] than in healthy pregnant women [10.05 (6.08-16.03) pg/mL] (both p<0.001). Furthermore, EOPs had significantly higher BNP levels as compared to LOP patients (p<0.001). A BNP cut-off <24.5 pg/mL had a negative-predictive value of 85.1% excluding preeclampsia. There was a significant inverse correlation between plasma BNP levels of EOP patients and sodium (p<0.05) and total protein concentrations (p<0.05). In the EOP group, a significant positive correlation was observed between plasma levels of BNP and hematocrit (p<0.05), serum potassium (p<0.05), urea (p<0.05) and 24-h proteinuria (p<0.05). CONCLUSIONS: BNP levels were significantly higher in EOP than in LOP patients. The cut-off value <24.5 pg/mL seems to be a powerful discriminative indicator excluding preeclampsia. The amount of proteinuria and total protein levels correlate with the elevation of the BNP levels. In EOP the extent of proteinuria is higher than in the LOP.
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Szabó et al. (2013) conducted an observational in Preeclampsia (n=80). Early-onset preeclampsia vs. Late-onset preeclampsia and healthy pregnant women was evaluated on B-type natriuretic peptide (BNP) levels (p=<0.001). BNP levels were significantly higher in early-onset preeclampsia (61.35 pg/mL) compared to late-onset preeclampsia (32.4 pg/mL) and healthy pregnant women (10.05 pg/mL) (p<0.001).
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