Key result
Cell-altered poliovirus virions undergo conformational changes that externalize the amino terminus of VP1, enabling attachment to liposomes and potentially facilitating cell entry.
The cell-induced conformational change in poliovirus externalizes the amino terminus of VP1, which is responsible for liposome attachment and likely plays a role in cell entry.
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Hypothesis-generating for poliovirus entry; validation in human and animal models needed before therapeutic implications.
Fricks et al. (1990) studied Poliovirus infection. Cell-altered poliovirus virions vs. Native and heat-inactivated virions was evaluated on Conformational transitions and liposome attachment. Cell-altered poliovirus virions undergo conformational changes that externalize the amino terminus of VP1, enabling attachment to liposomes and potentially facilitating cell entry.
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