November 21, 2013Journal of VirologyOpen Access

Cryo-Electron Microscopy Reconstruction Shows Poliovirus 135S Particles Poised for Membrane Interaction and RNA Release

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Population

Poliovirus 135S particles (n=117,330 particles)

Design

Preclinical

Authors

CBCarmen ButanYale University DFDavid J. FilmanHarvard University JHJames M. HogleHarvard University

Discussion

Member takes

Implication

Hypothesis-generating for enteroviral entry mechanisms; leaves open translation to human antivirals or vaccines.

Structured PICO

Population

Poliovirus 135S particles (n=117,330 particles)

Intervention

Cryo-electron microscopy reconstruction using Leginon and FREALIGN

Outcome

Structural details of the virus-to-135S transition and capsid protein rearrangements

Cryo-EM reconstruction of poliovirus 135S particles reveals structural rearrangements that facilitate membrane interaction and RNA release during infection.

Cite This Study

Butan et al. (2013) studied this question.

synapsesocial.com/papers/6a87cd7619ee2aac066c881d https://doi.org/10.1128/jvi.01949-13

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Cryo-Electron Microscopy Reconstruction Shows Poliovirus 135S Particles Poised for Membrane Interaction and RNA Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cryo-Electron Microscopy Reconstruction Shows Poliovirus 135S Particles Poised for Membrane Interaction and RNA Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider