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May 22, 2025Journal of Asian Pacific Society of CardiologyOpen Access

Clinical Characteristics and Outcomes of Southeast Asian Patients with Takotsubo Syndrome in Singapore

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Why the study?

Takotsubo syndrome has significant morbidity and mortality, but its clinical characteristics, outcomes, and risk factors in Southeast Asian patients were not well described.

Population

68 southeast-Asian patients with TTS in a single tertiary centre

Design

Single-centre retrospective study

Authors

SHSun-Ho HengIJIgnasius Aditya JapparNational Heart Centre SingaporeZDZee Pin DingFujian Medical University

Discussion

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Implication

May inform risk stratification for cardiogenic shock in Takotsubo syndrome; hypothesis-generating and requires prospective validation.

Structured PICO

P
Population
68 southeast-Asian patients with Takotsubo syndrome (TTS) treated at a single tertiary cardiology referral centre between January 2010 and December 2017
O
Outcome
In-hospital death and cardiogenic shockhard clinical

In a Singaporean cohort with Takotsubo syndrome, male sex and physical triggers were significantly associated with worse in-hospital outcomes including cardiogenic shock.

Cite This Study

Heng et al. (2025) studied this question.

synapsesocial.com/papers/6a0a58d297b2cd65685917a7https://doi.org/10.15420/japsc.2024.53
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications2022 · 400 citations
  2. 2Clinical characteristics and outcomes of South-East Asian patients with Takotsubo (stress-induced) cardiomyopathy2018 · 9 citations
  3. 3Cardiogenic Shock Complicating Takotsubo Syndrome: Sex‐Related Differences2024 · 9 citations
  4. 4Trigger‐Associated Clinical Implications and Outcomes in Takotsubo Syndrome: Results From the Multicenter GEIST Registry2023 · 47 citations
  5. 5“Reverse McConnell's Sign”: Interpreting Interventricular Hemodynamic Dependency and Guiding the Management of Acute Heart Failure during Takotsubo Cardiomyopathy2015 · 12 citations