Key result
PDA device closure linked to shorter QTc, QTd, and PR intervals in pediatric patients.
Why the study?
QT dispersion assesses arrhythmia risk in congenital heart disease, and pulmonary arterial hypertension alters ventricular repolarization homogeneity, but QT dispersion changes after PDA device closure and the effect of PAH remained to be evaluated.
Does PDA device closure improve QT dispersion and ventricular repolarization parameters in pediatric patients?
Observational (n=97)
Does PDA device closure improve QT dispersion and ventricular repolarization parameters in pediatric patients?
PDA device closure significantly improves ventricular repolarization parameters (QTc, QTd, PR interval) in pediatric patients, which may reduce the risk of arrhythmias.
May suggest lower arrhythmia risk after pediatric PDA closure; hypothesis-generating, needs randomized confirmation.
BACKGROUND: Numerous studies have shown that QT dispersion (QTd) can be a suitable criterion for risk assessment of arrhythmia in patients with congenital heart disease. Pulmonary arterial hypertension (PAH) increases the risk of cardiac arrhythmia by changing ventricular repolarization homogeneity. In this study, we assessed QTd changes after PDA device closure and the effect of PAH on these changes. METHODS: Between October 2018 and March 2021, 97 patients (48 males; 49 females; mean age 31.36 ± 4.26 months; range 3 months to 14 years) who satisfied the primary inclusion criteria and did not meet the exclusion criteria and underwent PDA device closure intervention were included in the study. Echocardiography was performed before the procedure. QT corrected (QTc), and QTd and PR intervals were measured according to the patients' standard 12-lead ECGs in two periods, preoperative (1 day) and after (3 months). RESULTS: In the general group, QTc and QTd decreased significantly after PDA closure. Based on our classification of the patients in two groups of high PAP and normal PAP, the three parameters QTc, QTd, and PR interval were assessed separately in the two groups. All three parameters decreased significantly in the normal PAP and high PAP groups. CONCLUSIONS: However, a left-to-right shunt through the patent ductus arteriosus can affect ventricular repolarization; this effect seems to be particularly more significant when there is pulmonary hypertension.
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Khalilian et al. (2022) conducted an observational in Patent ductus arteriosus (n=97). PDA device closure vs. Preoperative baseline was evaluated on Changes in QTc, QTd, and PR intervals. PDA device closure significantly decreased QTc, QTd, and PR intervals at 3 months post-procedure in pediatric patients, regardless of pulmonary artery pressure status.
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