Key Points
- To evaluate risk factors for mortality in patients with cardiac-device related infection through clinical and echocardiographic assessment.
- Retrospective evaluation of 210 patients with cardiac-device related infection from 1995 to 2006.
- Data extracted included clinical and echocardiographic variables, treatment strategies, and 6-month outcomes.
- Multivariable Cox proportional hazards models were utilized to determine associations with mortality.
- All-cause 6-month mortality rate was 18% (n=37).
- Independent mortality risk factors included systemic embolization (HR 7.11, 95% CI 2.74-18.48), tricuspid regurgitation (HR 4.24, 95% CI 1.84-9.75), and abnormal right ventricular function (HR 3.59, 95% CI 1.57-8.24).
- Abnormal renal function was also associated with increased risk of death (HR 2.98, 95% CI 1.17-7.59).
Structured PICO
PPopulation210 patients with cardiac-device related infection (pacemakers and implantable cardioverter defibrillators), mean age 63+/-17 years, 72 (44%) women, treated at the University of Michigan between 1995 and 2006.
OOutcome6-month all-cause mortalityhard clinical
Systemic embolization, moderate or severe tricuspid regurgitation, abnormal right ventricular function, and abnormal renal function are strong independent predictors of 6-month mortality in patients with cardiac device-related infections.