Key result
NAFLD is strongly linked to atherosclerosis, potentially driven by insulin resistance, dyslipidemia, and inflammation.
This review summarizes the mechanisms linking nonalcoholic fatty liver disease and atherosclerosis, highlighting NAFLD as an active contributor to cardiovascular disease pathogenesis.
May prompt NAFLD inclusion in CV risk assessment; leaves open whether targeting it alters atherosclerosis outcomes.
Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.
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Xu et al. (2015) conducted a review in Nonalcoholic fatty liver disease and atherosclerosis. Nonalcoholic fatty liver disease is highly associated with atherosclerosis and may contribute to its pathogenesis through mechanisms including insulin resistance, dyslipidemia, and inflammation.
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