Key result
Non-alcoholic fatty liver disease is linked to atherosclerosis and may increase the risk of vascular events through altered lipid-glucose metabolism, hypertension, and systemic inflammation.
Why the study?
The course of NAFLD is not fully understood, and clinical studies have highlighted an association with atherosclerosis and increased vascular risk.
This review highlights the pathophysiological and clinical links between non-alcoholic fatty liver disease and an increased risk of atherosclerosis and vascular events.
NAFLD may warrant vascular risk vigilance in practice; leaves open whether interventions targeting it reduce events.
Non-alcoholic fatty liver disease (NAFLD) is a common disease defined by excess fat deposition in the liver. The course of NAFLD is not fully understood, however, some pathogenic mechanisms have been identified. Accumulation of fat in liver cells is associated with insulin resistance, central obesity, triglyceride accumulation in the liver and hepatic fatty acid metabolism dysregulation that cause steatosis. The other process leads to hepatocyte inflammation and necrosis, which leads to severe hepatic disease; non-alcoholic steatohepatitis. Many clinical studies have underlined the link between NAFLD and atherosclerosis. NAFLD may alter the balance lipid-glucose metabolism as well as increase the risk of hypertension and systemic inflammation. This results in a greater risk of vascular events. The present review considers the link between NAFLD and atherosclerosis.
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Şevket Balta (2022) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Non-alcoholic fatty liver disease (NAFLD) was evaluated. Non-alcoholic fatty liver disease is linked to atherosclerosis and may increase the risk of vascular events through altered lipid-glucose metabolism, hypertension, and systemic inflammation.
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