Key result
Angiotensin II induces S-glutathiolation of Ras on Cys(118) via H(2)O(2) from NAD(P)H oxidase, increasing Ras activity and leading to p38 and Akt phosphorylation and protein synthesis.
S-glutathiolation of Ras on Cys(118) acts as a redox-sensitive signaling switch mediating Angiotensin II-induced hypertrophic signaling in vascular smooth muscle cells.
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Hypothesis-generating for redox Ras signaling in vascular hypertrophy; requires human validation before any clinical relevance.
Adachi et al. (2004) studied Vascular hypertrophy. Angiotensin II was evaluated on Ras activity, S-glutathiolation of Ras, p38 and Akt phosphorylation, and protein synthesis. Angiotensin II induces S-glutathiolation of Ras on Cys(118) via H(2)O(2) from NAD(P)H oxidase, increasing Ras activity and leading to p38 and Akt phosphorylation and protein synthesis.
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