What does this research mean for the field?

Angiotensin II stimulates a biphasic production of reactive oxygen species in vascular smooth muscle cells, where the rapid phase depends on protein kinase C and the sustained phase requires a signaling cascade involving c-Src, EGF receptor transactivation, phosphatidylinositol-3-kinase, and Rac. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 5, 2002Circulation Research

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

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Population

Vascular smooth muscle cells

Design

Preclinical

Authors

PSPuvi SeshiahHealth Net DWDavid S. WeberCarnegie Mellon University PRPetra RočićSam Houston State University

Discussion

Member takes

Implication

May guide phase-specific ROS inhibitor development in hypertension models; leaves open translation to human vascular disease.

Structured PICO

Population

Vascular smooth muscle cells

Intervention

Angiotensin II stimulation (with various inhibitors including Clostridium difficile toxin A, dominant-negative Rac, wortmannin, LY294002, AG1478, and PP1)

Outcome

Reactive oxygen species (ROS) production and NAD(P)H oxidase activitysurrogate

Angiotensin II stimulates ROS production in vascular smooth muscle cells via a biphasic mechanism involving PKC for the rapid phase and c-Src, EGFR transactivation, PI3K, and Rac for the sustained phase.

Cite This Study

Seshiah et al. (2002) studied this question.

synapsesocial.com/papers/6a1d237d73c56dd1bd2f3faa https://doi.org/10.1161/01.res.0000033523.08033.16

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Angiotensin II Stimulation of NAD(P)H Oxidase Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider