Synthesis and Biological Screening of Novel 1,3,4-Thiadiazole Derivatives With Antimicrobial and Antioxidant Properties

The antibacterial and antioxidant activities of six novel 1,3,4-thiadiazole derivatives were evaluated. The compounds exhibited significant antibacterial effects against Listeria monocytogenes, Proteus mirabilis, and Pseudomonas aeruginosa and moderate antifungal activity against Candida albicans. Antiradical activity was determined using a DPPH assay, with compound 3 demonstrating the highest effectiveness (59.9%). The lipid peroxidation inhibition assay revealed compound 3 as the most potent antioxidant, reducing malondialdehyde (MDA) levels by 49.9%. These results highlight the potential of 1,3,4-thiadiazole derivatives for therapeutic applications.