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May 18, 2026JCR Journal of Clinical RheumatologyOpen Access

Preinfusion Glucocorticoid Reduction and Elimination in Patients With Uncontrolled Gout on Pegloticase and Methotrexate: A Case Series

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Authors

JAJohn AlbertZVZana VranicBLBrian LaMoreaux

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Overview

Case series examines glucocorticoid dose reduction and elimination in uncontrolled gout patients, suggesting feasibility.

Key Points

  • This study aims to investigate the feasibility of reducing or eliminating preinfusion glucocorticoids in uncontrolled gout patients treated with pegloticase and methotrexate.
  • Retrospective case series conducted in a single rheumatology practice from January 2020 to April 2023.
  • Patients receiving pegloticase with methotrexate underwent preinfusion methylprednisolone dose reduction or elimination.
  • Assessment included serum urate levels and safety evaluations of adverse events.
  • At 24 weeks, 83% of patients were responders (SU <6 mg/dL), and 75% maintained response post-GC reduction.
  • 83% of patients experienced gout flares, while no infusion reactions were reported.
  • Patients received a mean of 14.3 pegloticase infusions, ceasing glucocorticoids after about 7.6 infusions.

Cite This Study

Albert et al. (2026) studied this question.

synapsesocial.com/papers/6a0aad2a5ba8ef6d83b70b5ehttps://doi.org/10.1097/rhu.0000000000002336
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Also Consider

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