Key result
Completely normal ECGs present in just 1.6% of HCM patients and are linked to milder disease.
Why the study?
A small subgroup of patients with milder hypertrophic cardiomyopathy may present with a normal ECG, which can delay diagnosis.
Population
682 patients diagnosed with HCM by ESC criteria
Comparison
Normal ECG vs abnormal ECG
Design
Retrospective observational study
Authors
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Normal ECGs do not exclude hypertrophic cardiomyopathy; supports milder phenotype association but leaves open prospective validation.
Observational (n=682)
A completely normal ECG is rare (1.6%) in hypertrophic cardiomyopathy and is associated with a milder disease phenotype, but its presence does not exclude the diagnosis.
Guler et al. (2026) conducted an observational in Hypertrophic cardiomyopathy (n=682). Normal ECG vs. Abnormal ECG was evaluated on Prevalence of completely normal ECGs. A completely normal ECG was observed in only 1.6% of patients with hypertrophic cardiomyopathy and was associated with indicators of milder disease severity.
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