Key result
Normal ECGs occur in ~2% of HCM patients, correlating with lower NT-proBNP and less LGE.
Why the study?
A small subgroup of HCM patients may present with a normal ECG, delaying diagnosis, but their prevalence and clinical characteristics were not well defined.
Population
682 patients with HCM
Comparison
Normal vs abnormal resting 12-lead ECG at diagnosis
Design
Retrospective observational study
Authors
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Normal ECGs remain rare in HCM and associate with milder phenotype; leaves open their role in risk stratification.
Observational (n=682)
Absolute Event Rate: 1.6% vs 98.4%
A completely normal ECG is exceedingly rare (1.6%) in hypertrophic cardiomyopathy and is associated with a milder clinical and imaging phenotype.
Guler et al. (2026) conducted an observational in Hypertrophic cardiomyopathy (n=682). Normal ECG vs. Abnormal ECG was evaluated on Prevalence of completely normal ECG. A completely normal ECG was present in only 1.6% of patients with hypertrophic cardiomyopathy and was associated with a milder phenotype, including lower NT-proBNP levels and less frequent LGE.
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