Key result
Longitudinal metabolic pinhole SPECT imaging with (123)I-BMIPP enabled the quantification of fatty acid metabolism kinetics in spontaneously hypertensive rats over 21 months.
This preclinical study demonstrates a novel technique for quantifying cardiac fatty acid metabolism using longitudinal pinhole SPECT imaging in a rat model of heart failure.
Enables longitudinal metabolic tracking in rodent hypertension models; leaves open clinical translation of (123)I-BMIPP SPECT.
The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR model. The fatty acid analog, (123)I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months. The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of (123)I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.
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Reutter et al. (2010) studied Hypertensive-related pathophysiology / heart failure. (123)I-labeled BMIPP longitudinal metabolic pinhole SPECT imaging vs. Wistar-Kyoto normal rats was evaluated on Fatty acid metabolism changes and kinetics of (123)I-BMIPP. Longitudinal metabolic pinhole SPECT imaging with (123)I-BMIPP enabled the quantification of fatty acid metabolism kinetics in spontaneously hypertensive rats over 21 months.
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