Key result
Myocardial stunning during CRRT is linked to a ~7-fold higher mortality risk.
Why the study?
Myocardial stunning is well-recognized in chronic hemodialysis patients but less studied in critically ill patients undergoing CRRT.
Does continuous renal replacement therapy associate with myocardial stunning in critically ill patients with acute kidney injury?
Observational (n=38)
No
Does continuous renal replacement therapy associate with myocardial stunning in critically ill patients with acute kidney injury?
Myocardial stunning is highly prevalent (60.5%) in critically ill patients undergoing CRRT and is associated with significantly higher mortality.
Answers are grounded in this paper and cite their sources.
Stunning during CRRT identifies higher-mortality patients; leaves open causality and requires prospective validation.
Introduction: Myocardial stunning, a temporary reduction in cardiac contractility, is well-recognized in chronic hemodialysis patients but less studied in critically ill patients undergoing continuous renal replacement therapy (CRRT). Methods: A prospective observational 11-month study included 38 intensive care unit (ICU) patients with acute kidney injury at Mohammed V University Hospital. Myocardial stunning was evaluated using echocardiographic parameters such as global longitudinal strain and left ventricular ejection fraction. Results: Myocardial stunning was observed in 60.5% of patients. It was strongly associated with increased vasopressor requirements, longer ICU stays, and higher mortality (47.8% vs. 6.7%). Conclusion: The high incidence of myocardial stunning in critically ill patients undergoing CRRT highlights the need for vigilant cardiac monitoring and targeted interventions to improve patient outcomes.
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Berrichi et al. (2025) conducted an observational in Acute kidney injury (n=38). Continuous renal replacement therapy (CRRT) vs. Patients without myocardial stunning was evaluated on Mortality in patients with vs. without myocardial stunning. Myocardial stunning was observed in 60.5% of critically ill patients undergoing CRRT and was associated with higher mortality compared to those without stunning.
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