Key result
Metabolically unhealthy phenotype linked to ~95% higher prevalence of cardiovascular disease or stroke.
Why the study?
Is the metabolically healthy obese phenotype associated with a higher prevalence of cardiovascular diseases or stroke compared to other metabolically healthy groups?
Cross-Sectional (n=3,695)
Is the metabolically healthy obese phenotype associated with a higher prevalence of cardiovascular diseases or stroke compared to other metabolically healthy groups?
Absolute Event Rate: 8.6% vs 4.4%
p-value: p=<0.001
Metabolic health status, rather than obesity alone, is more closely associated with the prevalence of cardiovascular diseases and stroke.
Suggests metabolic status drives cardiovascular risk more than obesity alone; leaves open whether targeting metabolic.
Mounting evidence suggests that not all obese subjects are at increased cardiovascular risk. However, the relationship between the metabolically healthy obese (MHO) phenotype and cardiovascular diseases (CVDs) or stroke remains unclear. Therefore, we retrospectively investigated the prevalence of CVDs or stroke according to metabolic health with obese.We studied 3695 subjects (40-85 years) from the Fifth Korean National Health and Nutrition Examination Survey. Participants were divided into 2 groups and 6 subgroups based on the body mass index (BMI) and metabolic syndrome (MetS) components: healthy (exhibiting none of the 5 MetS components) with the followings: healthy-normal weight (BMI < 23 kg/m), healthy-overweight (BMI = 23-24.9 kg/m), and healthy-obese (BMI ≥ 25 kg/m); and unhealthy (exhibiting 2 or more MetS components) with the followings: unhealthy-normal weight, unhealthy-overweight, and unhealthy-obese.In the healthy group (n = 1726), there were 76 CVDs or stroke patients (4.4%), whereas in the unhealthy group (n = 1969), there were 170 (8.6%). The prevalence was significantly different between the 2 groups (P < 0.001). However, the prevalence was not significantly different among healthy subgroups (P = 0.4072). The prevalence in unhealthy subgroups also demonstrated no statistically significant difference (P = 0.3798).We suggest that the prevalence of CVDs or stroke is different between metabolically healthy and unhealthy phenotype. Furthermore, MHO did not reveal higher CVDs or stroke prevalence rather than metabolically healthy other groups. Additional cohort studies are needed to explain causality between CVDs or stroke incidence and subjects exhibiting the MHO phenotype.
No takes yet. Share an insight, caveat, or question.
Byun et al. (2016) conducted a cross-sectional in Cardiovascular diseases or stroke (n=3,695). Metabolically unhealthy phenotype vs. Metabolically healthy phenotype was evaluated on Prevalence of cardiovascular diseases or stroke (p=<0.001). The metabolically unhealthy phenotype was associated with a significantly higher prevalence of cardiovascular diseases or stroke (8.6%) compared to the metabolically healthy phenotype (4.4%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: