Why the study?
Various diseases are associated with obesity and metabolism, prompting investigation into the risk of cardiovascular disease across diverse metabolic obesity phenotypes.
Do metabolically healthy obesity and metabolically unhealthy obesity increase the risk of cardiovascular disease in adults without baseline CVD compared to metabolically healthy normal weight?
Population
1517 participants ≥25 years of age without CVD at baseline
Comparison
Four metabolic obesity phenotypes based on central obesity and metabolic health status
Design
Prospective observational study
Follow-up
14830.49 person-years
Authors
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MHO may confer intermediate CVD risk; leaves open whether phenotype-specific monitoring improves outcomes in larger cohorts.
Do metabolically healthy obesity and metabolically unhealthy obesity increase the risk of cardiovascular disease in adults without baseline CVD compared to metabolically healthy normal weight?
Both metabolically healthy obesity and metabolically unhealthy obesity are associated with an increased risk of incident cardiovascular disease, suggesting that obesity even without metabolic abnormalities carries cardiovascular risk.
Liu et al. (2023) studied this question.
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