Why the study?
Various diseases are associated with obesity and metabolism, prompting investigation into the risk of cardiovascular disease across diverse metabolic obesity phenotypes.
Do metabolically healthy obesity and metabolically unhealthy obesity increase the risk of cardiovascular disease in adults without baseline CVD compared to metabolically healthy normal weight?
Do metabolically healthy obesity and metabolically unhealthy obesity increase the risk of cardiovascular disease in adults without baseline CVD compared to metabolically healthy normal weight?
Both metabolically healthy obesity and metabolically unhealthy obesity are associated with an increased risk of incident cardiovascular disease, suggesting that obesity even without metabolic abnormalities carries cardiovascular risk.
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MHO may confer intermediate CVD risk; leaves open whether phenotype-specific monitoring improves outcomes in larger cohorts.
Objectives:Various diseases are associated with obesity and metabolism. We sought to investigate the risk of cardiovascular disease (CVD) in diverse metabolic obesity phenotypes. Methods and Results:A prospective observational study of 1517 participants ≥25 years of age without CVD at baseline was conducted. Participants were categorized into four groups based on the condition of central obesity and metabolic health status: metabolically healthy normal weight, metabolically healthy obesity (MHO), metabolically unhealthy normal weight, and metabolically unhealthy obese (MUO). A multivariate Cox regression analysis was used to analyze the relationship between different obesity phenotypes and CVD. During 14830.49 person-years of follow-up, there were 244 incident cases of CVD. Of the 1517 participants, 72 (4.75%) and 812 (53.53%) were classified as having MHO and MUO, respectively. MHO and MUO had a tendency toward a higher risk of CVD [adjusted hazard ratios (HRs) = 1.49, 95% confidence interval (CI): 1.11–2.02 and HR = 1.25, 95% CI: 1.00–1.55, respectively] based on the waist circumference criterion.
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Liu et al. (2023) studied this question.
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