Why the study?
Data on the cardiovascular risk of the metabolically healthy obesity phenotype and the effect of transitioning to an unhealthy status were inconsistent.
Does transition from metabolically healthy obesity to metabolic syndrome increase the incidence of cardiovascular disease in adults?
Population
6758 participants aged ≥ 20 years (41.6% men)
Comparison
Persistent MHNW, persistent MHO, transitional MHO, and MUO groups
Design
Population-based cohort study
Follow-up
Median follow-up of 15.9 years
Key result
Transition from metabolically healthy obesity to metabolic syndrome over 15.9 years increased the risk of cardiovascular disease in males (HR 1.55) but not in females (HR 0.93).
Authors
Loading...
Persistent MHO showed no excess CVD risk; leaves open whether transition to unhealthy status drives outcomes in observational cohorts.
Cohort (n=6,758)
Does transition from metabolically healthy obesity to metabolic syndrome increase the incidence of cardiovascular disease in adults?
Hazard Ratio: 1.55 (95% CI 1.02–2.37)
Transition from metabolically healthy obesity to a metabolically unhealthy state increases the risk of cardiovascular disease in men, highlighting the dynamic nature of obesity phenotypes and the need for ongoing metabolic monitoring.
Hosseinpanah et al. (2020) conducted a cohort in Metabolically healthy obesity (n=6,758). Transition from metabolically healthy obesity to metabolic syndrome vs. Persistent metabolically healthy normal weight was evaluated on Cardiovascular disease incidence (HR 1.55, 95% CI 1.02-2.37). Transition from metabolically healthy obesity to metabolic syndrome over 15.9 years increased the risk of cardiovascular disease in males (HR 1.55) but not in females (HR 0.93).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: